Optimizing non-natural protein function with directed evolution
نویسندگان
چکیده
منابع مشابه
Optimizing non-natural protein function with directed evolution.
Developing technologies such as unnatural amino acid mutagenesis, non-natural cofactor engineering, and computational design are generating proteins with novel functions; these proteins, however, often do not reach performance targets and would benefit from further optimization. Evolutionary methods can complement these approaches: recent work combining unnatural amino acid mutagenesis and phag...
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ژورنال
عنوان ژورنال: Current Opinion in Chemical Biology
سال: 2011
ISSN: 1367-5931
DOI: 10.1016/j.cbpa.2010.11.020